hrp0097rfc8.5 | Fat, metabolism and obesity 2 | ESPE2023

Effects of leptin knockdown on a human preadipocyte model

Fuchs Lasse , Jasaszwili Mariami , Richter Sandy , Kirstein Anna , Engelberger Felipe , Künze Georg , Meiler Jens , Lemke Johannes , Kiess Wieland , Le Duc Diana , Garten Antje

Obesity presents a major worldwide challenge, due to its numerous, severe adverse effects on health. This leads to a necessity to further investigate the mechanisms underlying lipid accumulation. The adipocytokine leptin may contribute to this process. While there already has been thorough research into central leptin action, deepening our understanding of leptin’s effects on whole-body energy homeostasis, relatively little is known about its auto- and paracrine effects....